Cincinnati's Culinary Destination
Nestled along Queen City Avenue, 221 Restaurant celebrates the art of gathering — seasonal ingredients, craft cocktails, and an atmosphere that turns ordinary evenings into unforgettable moments.
Queen City Ave, Cincinnati — where flavor finds its home
Our Story
221 Restaurant was born from a simple conviction: that dining out should feel like coming home to something extraordinary. Located in the heart of Cincinnati, our kitchen draws from regional farms, coastal traditions, and the bold flavors that make the Midwest unmistakable.
Every dish on our menu is a conversation — between the season and the stove, between tradition and invention. We source what matters, craft what counts, and serve with the kind of warmth that only comes from caring deeply about what you put on the plate.
Ingredient-driven menu
Farm-sourced produce
Signature cocktails
The Space
Guest Voices
The kind of place that makes you slow down. Every course felt intentional, and the atmosphere struck the perfect balance between refined and welcoming.
Local publication
We celebrated an anniversary here and the evening unfolded exactly as it should — great food, attentive service, and a wine list that surprised us at every turn.
Verified guest
221 has become our go-to for hosting out-of-town clients. The menu impresses, the space works, and the attention to detail speaks for itself.
Regular guest
Find Us
2198 Queen City Ave
Cincinnati, OH 45214-1028
Tuesday – Thursday: 5:00 PM – 10:00 PM
Friday – Saturday: 5:00 PM – 11:00 PM
Sunday: 4:00 PM – 9:00 PM
Monday: Closed
